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mutations given The reality that, as stated MBL77 beneath, CLL therapy is predicated on the presence or absence of those mutations. The present consensus is usually that, apart from clonal mutations, subclonal mutations using a variant allelic frequency ranging from five to ten% (and therefore beneath the threshold of detection by traditional molecular approaches) is also reported, whereas These by using a variant allelic frequency reduced than 5% shouldn't, but there is Considerably controversy close to these troubles which advice could change in the future.
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